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ea0063gp98 | Adrenal and Neuroendocrine - Basic | ECE2019

Methylation status and gene expression of steroidogenic enzymes in benign adrenocortical tumors

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Asioli Sofia , Maffeis Valeria , Vicennati Valentina , Pagotto Uberto , Fallo Francesco

Background: DNA methylation has been recognized as a putative regulatory mechanism for CYP11B2 in primary hyperaldosteronism. We aimed to investigate the DNA methylation and the expression of a panel of genes encoding several enzymes involved in steroidogenesis in adrenocortical benign tumors.Methods: We collected a total of 60 adrenocortical tissues, including 9 non-functioning adrenal adenomas, 9 adenomas associated with autonomous cortisol se...

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ea0070aep43 | Adrenal and Cardiovascular Endocrinology | ECE2020

CYP11B2 DNA methylation pattern is discordant in aldosterone-producing adenomas and in concurrent aldosterone-producing cell clusters

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Maffeis Valeria , Asioli Sofia , Vicennati Valentina , Pagotto Uberto , Fassina Ambrogio , Fallo Francesco

Background: Previous studies have shown an association between low CYP11B2 DNA methylation levels and high CYP11B2 mRNA levels in aldosterone-producing adenoma (APA), suggesting that epigenetic mechanisms play a pivotal role for regulating CYP11B2 function in primary aldosteronism. It has been proposed that aldosterone-producing cell clusters (APCCs) may become a source of autonomous aldosterone production when evolving into APA.Aim: Our aim was to deter...

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Endocrine Abstracts

Methylation status and gene expression of steroidogenic enzymes in benign adrenocortical tumors

CYP11B2 DNA methylation pattern is discordant in aldosterone-producing adenomas and in concurrent aldosterone-producing cell clusters

BiosciAbstracts